Saturday 9 January 2016

VIVIX - Sokongan Kuat, Hasil Hebat


Faktor-faktor seperti tekanan, pemakanan yang tidak seimbang, dan toksin persekitaran boleh melemahkan pertahanan semulajadi sel-sel tubuh, tenaga sel semakin berkurangan, kerosakan DNA dan prestasi sel menurun. Semua ini boleh menyumbang kepada penuaan selular kita.

Kajian klinikal menunjukkan bahan-bahan aktif dalam Vivix® memberi kesan positif kepada empat mekanisma penuaan pada tahap sellular.

Pertahanan Sel













Satu kajian klinikal yang diterbitkan dalam The Journal of Endokrinologi dan Metabolisme menunjukkan bahawa bahan utama dalam Vivix menyekat penanda utama tindak balas tekanan biologi selepas pengambilan yang tinggi lemak dari sarapan makanan segera berjumlah 930 kalori*

*Nama kajian: A Resveratrol and Polyphenol Preparation Suppresses Oxidative and Inflammatory Response to a High-Fat, High-Carbohydrate Meal. Tarikh publish: 2 Februari 2011.

Tenaga Sel
















Satu kajian makmal di sebuah universiti terkemuka menunjukkan bahawa bahan utama dalam Vivix meningkatkan mitokondria (stesen jana kuasa sel yang menghasilkan tenaga) dengan ketara.

** Dalam kajian makmal di sebuah universiti terkemuka, Vivix = resveratrol + proprietari polifenol campuran.

Baikpulih Sel















Kajian makmal menunjukkan bahawa bahan-bahan utama Vivix membantu melindungi daripada kerosakan DNA, menyokong replikasi DNA untuk fungsi sel yang sihat.

Prestasi Sel












Hasil daripada kajian makmal di sebuah universiti terkemuka menunjukkan bahawa bahan utama dalam Vivix menghalang pembentukan protein AGE, yang boleh menyebabkan kerosakan sel.


1) Rujukan Pertahanan Sel
Ghanim h, Sia Cl, Korzeniewski K, lohano T, Abuaysheh S, Marumganti A, Chaudhuri A, Dandona P. A resveratrol and Polyphenol Preparation Suppresses oxidative and inflammatory Stress Response to a High-Fat, High-Carbohydrate Meal. J Clin Endocrinol Metab.96(5):1409-1414, 2011.

Noratto GD, Angel-Morales G, Talcott ST, Mertens-Talcott Su. Polyphenolics from Açaí (Euterpe Oleracea Mart.) and red Muscadine Grape (Vitis Rotundifolia) Protect human umbilical Vascular Endothelial Cells (huVEC) from Glucose – and lipopolysaccharide (lPS-)induced inflammation and Target MicrornA-126.
J Agric Food Chem 59(14):7999-8012, 2011.

McDougald lr, hofacre C, Mathis G, fuller l, hargrove Jl, Greenspan P, hartle DK. Enhancement of resistance to Coccidiosis and necrotic Enteritis in Broiler Chickens by Dietary Muscadine Pomace. Avian Dis 52(4):646-651, 2008.

Ho l, Chen lh, wang J, Zhao w, Talcott ST, ono K, Teplow D, humala n, Cheng A, Percival SS, ferruzzi M, Janle E, Dickstein Dl, Pasinetti GM. heteroge- neity in red wine Polyphenolic Contents Differentially influences Alzheimer’s Disease-Type neuropathology and Cognitive Deterioration. J Alzheimers Dis 16(1):59-72, 2009.

Bralley EE, hargrove Jl, Greenspan P, hartle DK. Topical Anti-inflammatory Activities of Vitis Rotundifolia (Muscadine Grape) Extracts in the Tetradecanoylphor- bol Acetate Model of Ear inflammation. J Med Food 10(4):636-642, 2007.

Greenspan P, Bauer JD, Pollock Sh, Gangemi JD, Mayer EP, Ghaffar A, hargrove Jl, hartle DK. Anti-inflammatory Properties of the Muscadine Grape (Vitis Rotundifolia).
J Agric Food Chem 53(22):8481-8484, 2005.

Tate P, God J, Bibb r, lu Q, larcom ll. inhibition of Metalloproteinase Activity by fruit Extracts. Cancer Lett 212(2):153-158, 2004.

Ungvari Z, orosz Z, rivera A, labinskyy n, Xiangmin Z, olson S, Podlutsky A, Csiszar A. resveratrol increases Vascular oxidative Stress resistance.
Am J Physiol Heart Circ Physiol 292(5):h2417-h2424, 2007.

Csiszar A, Smith K, labinskyy n, orosz Z, rivera A, ungvari Z. resveratrol Attenuates Tnf-Alpha-induced Activation of Coronary Arterial Endothelial Cells: role of NF-KappaB inhibition. Am J Physiol Heart Circ Physiol 291(4):h1694-h1699, 2006.

Donnelly lE, newton r, Kennedy GE, fenwick PS, leung rh, ito K, russell rE, Barnes PJ. Anti-inflammatory Effects of resveratrol in lung Epithelial Cells: Molecular Mechanisms. Am J Physiol Lung Cell Mol Physiol 287(4):l774-l783, 2004.

Shigematsu S, ishida S, hara M, Takahashi n, Yoshimatsu h, Sakata T, Korthuis rJ. resveratrol, a red wine Constituent Polyphenol, Prevents Superoxide-Dependent inflammatory responses induced by ischemia/reperfusion, Platelet-Activating factor, or oxidants. Free Radic Biol Med 34(7):810-817, 2003.

2) Rujukan Tenaga Sel
lagouge M, Argmann C, Gerhart-hines Z, Meziane h, et al. resveratrol improves Mitochondrial function and Protects Against Metabolic Disease by Activating SirT1 and PGC-1. Cell 127(6):1109-1122, 2006.

Dasgupta B, Milbrandt J. resveratrol Stimulates AMP Kinase Activity in neurons, Proc Natl Acad Sci USA 104(17):7217-7222, 2007.

St-Pierre J, Drori S, uldry M, Silvaggi J, rhee J, Jäger S, handschin C, et al. Suppression of reactive oxygen Species and neurodegeneration by the PGC-1 Transcriptional Coactivators. Cell 127(2):397-408, 2006.

Civitarese A, Carling S, heilbronn l, hulver M, ukropcova B, Deutsch w, Smith S, ravussin E, Calorie restriction increases Muscle Mitochondrial Biogenesis in Healthy Humans. PLoS Medicine 4(3):e76, 2007.

lopez-lluch G, irusta P, navas P, de Cabo r. Mitochondrial Biogenesis and healthy Aging. Exp Gerontol 43(9):813-819, 2008.

3. Rujukan Baikpulih Sel
Usha S, irudayam MJ, Malathi r. interaction of resveratrol and Genistein with nucleic Acids. J Biochem Molec Biol 38(2):198-205, 2005.

niture S, Velu C, Smith Q, Bhat J, Srivenugopal K. increased Expression of the MGMT repair Protein Mediated by Cysteine Prodrugs and Chemopreventive Natural Products in Human Lymphocytes and Tumor Lines. Carcinogenesis 28(2):378-389, 2007.

Yang S, irani K, heffron S, Jurnack f, Meyskens f. Alterations in the Expressions of the Apurinic/Apyrimidinic Endonuclease-1/redox factor-1 (APE/ref-1) in human Melanoma and identification of the Therapeutic Potential of resveratrol as an APE/ref-1 inhibitor. Mol Cancer Ther 4(12):1923-1935, 2005.

Zahid M, Gaikwad nw, rogan EG, Cavalieri El. inhibition of Depurinating Estrogen-DnA Adduct formation by natural Compounds. Chem Res Toxicol 20(12): 1947-1953, 2007.

Chakraborty S, roy M, Bhattacharya rK. Prevention and repair of DnA Damage by Selected Phytochemicals as Measured by Single-Cell Gel Electrophoresis. J Environ Pathol Toxicol Oncol 23(3): 215-226, 2004.

Gatz SA, Keimling M, Baumann C, Dörk T, Debatin KM, fulda S, wiesmüller l. resveratrol Modulates DnA Doublestrand Break repair Pathways in an ATM/ATr-p53-and–nbs1-Dependent Manner. Carcinogenesis 29(3): 519-527, 2008.

God JM, Tate P, larcom ll. Anti-Cancer Effects of four Varieties of Muscadine Grape. J Med Food 10(1):54-59, 2007.

4. Rujukan Prestasi Sel
Farrar J, hartle D, hargrove J, Greenspan P. inhibition of Protein Glycation by Skins and Seeds of the Muscadine Grape. BioFactors 30(3):193-200, 2007. hudson T, hartle D, hursting S, nunez n, wang T, Young h, Arany P, Green J. inhibition of Prostate Cancer Growth by Muscadine Grape Skin Extract and Resveratrol through Distinct Mechanisms. Cancer Res 67(17):8396-8405, 2007.

Bralley E, Greenspan P, hargrove J, hartle D. inhibition of hyarluronidase Activity by Vitis Rotundifolia (Muscadine) Berry Seeds and Skins. Pharmaceutical Biology 45(9):667-673, 2007.

Ramasamy r, Vannucci S, Shi Du Yan S, herold K, Yan S, Schmidt A. Advanced Glycation End Products and rAGE: A Common Thread in Aging, Diabetes, Neurodegeneration, and inflammation. Glycobiology 15(7):16r– 28r, 2005.

Mellen PB, Daniel Kr, Brosnihan KB, hansen KJ, herrington DM. Effect of Muscadine Grape Seed Supplementation on Vascular function in Subjects with or At risk for Cardiovascular Disease: A randomized Crossover Trial. J Am Coll Nutr 29(5):469-475, 2010.

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